They circulate in the blood, where they have various specific functions.
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Generally, peptides and hormones are used by patients suffering from diseases related to growth hormone deficiency to keep their condition from leading to poor bone density, a leaky gut, or inflammatory conditions. The little mouse is an established animal model for assessing the direct GHRH-independent effects of GHSs and ghrelin on pituitary somatotroph cells (33-35).
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